中間體
發布日期：2025-10-22 瀏覽次數：201
| Pharmaceutical Intermediates List | ||
| Usage | Product | CAS No. |
| Lamivudine | L-Menthyl glyoxylate monohydrate(L-MGH) | 111969-64-3 |
| (2R,5R)-5-Hydroxy-1,3-oxathiolane-2-carboxylic acid(1R,2S,5R)-5-methyl-2-(1-methylethyl)-cyclohexyl ester(HME) | 147126-62-3 | |
| (2R,5S)-5-(4-amino-2-oxo-1(2H)-pyrimidin-1-yl)-[1,3]oxathiolane-2-carboxylic acid(1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl ester(CME) | 147027-10-9 | |
| (2R,5S)-4-Amino-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2-(1H)-pyrimidinone salicylate (Lamivudine Salicylate) | 173522-96-8 | |
| Zidovudine | 5-O-Triphenylmethyl-2-deoxy-2,3-didehyrothymidine | 25442-42-6 |
|
Tenofovir disoproxil
fumarate
|
(R)-(+)-9-(2-Hydroxypropyl)adenine | 14047-28-0 |
| (R)-9-(2-Phosphonomethoxypropyl)Adenine(PMPA) | 147127-20-6 | |
|
Tenofovir
alafenamide
fumarate
|
(R)-(+)-9-(2-Hydroxypropyl)adenine | 14047-28-0 |
| (R)-9-(2-Phosphonomethoxypropyl)Adenine(PMPA) | 147127-20-6 | |
| Phenyl hydrogen [(R)-1-(6-amino-9H-purin-9-yl)propan-2-yloxy]methylphosphonate | 379270-35-6 | |
| Emtricitabine |
(2R,5S)-5-(4-Amino-5-fluoro-2-oxo-1(2H)-pyrimidinyl)-1,3-oxathiolane-2-carboxylic
acid(1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl ester(FCME)
|
764659-72-5 |
| Efavirenz | (S)-1-(2-Amino-5-chlorophenyl)-1-(trifluoromethyl)-3-cyclopropyl-2-propyn-1-ol | 209414-27-7 |
|
(S)-5-Chloro-alpha-(cyclopropylacetenyl)-2-[((4-methoxyphenyl)methyl)amino]-alpha-
(trifluoromethyl)benzenemethanol
|
173676-60-3 | |
| Entecavir |
6-(Benzyloxy)-9-(1S,3R,3S)-4-(benzyloxy)-3-(benzyloxymethyl)-2-methylenecyclopentyl)-
N-(4-methoxyphenyl)diphenylmethy1)-9H-purin-2-amine(Ent-VII)
|
142217-81-9 |
|
2-Amino-1,9-dihydro-9-[(1S,3R,4S)-4-(benzyloxy)-3-(benzyloxymethyl)-2-
methylenecyclopentyl]-6H-purin-6-one
|
142217-81-0 | |
| Ritonavir | ((5-Thiazolyl)methyl)-(4-nitrophenyl)carbonate(NCT) | 144163-97-3 |
|
N-[2-Isopropylthiazol-4-ylmethyl(methyl)-carbamoyl]-L-valine
(MTV-III)
|
154212-61-0 | |
|
(2S,3S,5S)-5-t-Butyloxycarbonylamino-2-amino-3-hydroxy-1,6-diphenylhexane 1/2
succinate salt (BDH succinate salt)
|
183388-64-9 | |
|
(2S,3S,5S)-5-t-Butyloxycarbonylamino-2-amino-3-hydroxy-1,6-diphenylhexane (BDH
PURE)
|
144163-85-9 | |
| Lopinavir |
N-(4-Amino-1-benzyl-3-hydroxy-5-phenyl-pentyl)-3-methyl-2-(2-oxo-tetrahydro-
pyrimidin-1-y1)-butyramide 5-oxopyrrolidine-2-carboxylic acid(THP)
|
192726-06-0 |
|
Rilpivirine
hydrochloride
|
4-[(4-Hydroxy-2-pyrimidinyl)amino]benzonitrile | 189956-45-4 |
| 4-[(4-Chloro-2-pyrimidinyl)amino]benzonitrile | 244768-32-9 | |
| (E)-3-(4-Amino-3,5-dimethylphenyl)-2-propenenitrile hydrochloride | 661489-23-2 | |
| Dolutegravir sodium |
(4R,12aS)-3,4,6,8,12,12a-Hexahydro-7-hydroxy-4-methyl-6,8-dioxo-2H-
pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid
|
1246616-73-8 |
|
(4R,12aS)-3,4,6,8,12,12a-Hexahydro-7-methoxy-4-methyl-6,8-dioxo-2H-
pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid
|
1335210-34-8 | |
|
(4R,12aS)-N-[(2,4-Difluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-methoxy-4-
methyl-6,8-dioxo-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide
|
1335210-35-9 | |
|
1-(2,2-Dimethoxyethyl)-5-methoxy-6-(methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-
carboxylic Acid
|
1335210-23-5 | |
| Abacavir sulfate |
N-[2-Amino-4-chloro-6-[[(1R,4S)-4-(hydroxymethyl)-2-cyclopenten-1-yl]amino]-5-
pyrimidinyl]formamide
|
171887-04-0 |
| (1S,4R)-4-(2-Amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol hydrochloride | 172015-79-1 | |
|
Oseltamivir
phosphate
|
ethyl(3R,4R,5S)-4-(tert-butylamino)-5-(diallylamino)-3-(pentan-3-yloxy)cyclohex-1-ene-
1-carboxylate hydrochloride
|
2778297-04-2 |
| ethyl(3R,4R,5S)-4-(N-(tert-butyl)acetamido)-5-(diallylamino)-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylate hydrochloride | 651324-08-2 | |
| ethyl(3R,4R,5S)-4-acetamido-5-amino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylate | 196618-13-0 | |
| Lafutidine | 2-Chloro-4-(1-piperidinylmethyl)pyridine | 146270-01-1 |
| (2-furanmethyl)thiopontoacetic acid-(4-nitrophenol)ester | 118287-86-8 | |
| Ursodeoxycholic acid | Chenodeoxycholic acid | 474-25-9 |
| Baricitinib | (4-(1-(1-ethoxyethyl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate | 1146629-76-6 |
| (4-(1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate | 1146629-77-7 | |
|
(4-(1-(3-(cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-
d]pyrimidin-7-yl)methyl pivalate
|
1187595-90-9 | |
| Iguratimod | N-(4-glycyl-5-methoxy-2-phenoxyphenyl)methanesulfonamide hydrochloride | 149436-41-9 |
| N-(2-(2-methoxy-4-(methylsulfonamido)-5-phenoxyphenyl)-2-0xoethyl)formamide | 149456-98-4 | |
| N-(2-(2-hydroxy-4-(methylsulfonamido)-5-phenoxyphenyl)-2-oxoethyl)formamide | 149457-03-4 | |
| Metronidazole | 2-Methylimidazole | 693-98-1 |
| 2-Methyl-5-nitroimidazole | 88054-22-2 | |
| 2-Methyl-4,5-dinitroimidazole | 19183-16-5 | |
| Molnupiravir | 2',3'-O-(1-methylethylidene)-Uridine 4-oxime 5'-(2-methylpropanoate) | 2346620-55-9 |
| Safinamide mesylate | 4-((3-fluorobenzyl)oxy)benzaldchyde | 66742-57-2 |
| (S)-2-(4-(3-fluorobenzyl)oxy)benzyl)amino)propanamide | 133865-89-1 | |
| Baloxavir marboxil | (12aR)-7-(hexyloxy)-3,4,12,12a-tetrahydro-1H-[1,4]Oxazino[3,4-c]pyrido[2,1-f][1,2,4]triazine-6,8-dione 4-methylbenzenesulfonate | 2136287-68-6 |
|
(12aR)-12-[(S)-7,8-difluoro-6,11-dihydrodibenzo[b,e]thiazepin-11-yl]-7-(n-hexoxy)-
3,4,12,12a-tetrahydro-1H-oxazino[3,4-c]pyridinopyrimidine[2,1-f][1,2,4]triazine-6,8-
dione methanesulfonate
|
2136287-69-7 | |
|
(12aR)-12-[(11S)-7,8-difluoro-6,11-dihydrodibenzo[b,e]thiepin-11-yl]-3,4,12,12a-
tetrahydro-7-hydroxy-1H-[1,4]oxazino[3,4-cpyrido[2,1-f][1,2,4]triazine-6,8-dione
|
1985605-59-1 | |
| Pharmaceutical Intermediates List | ||
| Usage | Product | CAS No. |
| Lamivudine | L-Menthyl glyoxylate monohydrate(L-MGH) | 111969-64-3 |
| (2R,5R)-5-Hydroxy-1,3-oxathiolane-2-carboxylic acid(1R,2S,5R)-5-methyl-2-(1-methylethyl)-cyclohexyl ester(HME) | 147126-62-3 | |
| (2R,5S)-5-(4-amino-2-oxo-1(2H)-pyrimidin-1-yl)-[1,3]oxathiolane-2-carboxylic acid(1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl ester(CME) | 147027-10-9 | |
| (2R,5S)-4-Amino-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2-(1H)-pyrimidinone salicylate (Lamivudine Salicylate) | 173522-96-8 | |
| Zidovudine | 5-O-Triphenylmethyl-2-deoxy-2,3-didehyrothymidine | 25442-42-6 |
|
Tenofovir disoproxil
fumarate
|
(R)-(+)-9-(2-Hydroxypropyl)adenine | 14047-28-0 |
| (R)-9-(2-Phosphonomethoxypropyl)Adenine(PMPA) | 147127-20-6 | |
|
Tenofovir
alafenamide
fumarate
|
(R)-(+)-9-(2-Hydroxypropyl)adenine | 14047-28-0 |
| (R)-9-(2-Phosphonomethoxypropyl)Adenine(PMPA) | 147127-20-6 | |
| Phenyl hydrogen [(R)-1-(6-amino-9H-purin-9-yl)propan-2-yloxy]methylphosphonate | 379270-35-6 | |
| Emtricitabine |
(2R,5S)-5-(4-Amino-5-fluoro-2-oxo-1(2H)-pyrimidinyl)-1,3-oxathiolane-2-carboxylic
acid(1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl ester(FCME)
|
764659-72-5 |
| Efavirenz | (S)-1-(2-Amino-5-chlorophenyl)-1-(trifluoromethyl)-3-cyclopropyl-2-propyn-1-ol | 209414-27-7 |
|
(S)-5-Chloro-alpha-(cyclopropylacetenyl)-2-[((4-methoxyphenyl)methyl)amino]-alpha-
(trifluoromethyl)benzenemethanol
|
173676-60-3 | |
| Entecavir |
6-(Benzyloxy)-9-(1S,3R,3S)-4-(benzyloxy)-3-(benzyloxymethyl)-2-methylenecyclopentyl)-
N-(4-methoxyphenyl)diphenylmethy1)-9H-purin-2-amine(Ent-VII)
|
142217-81-9 |
|
2-Amino-1,9-dihydro-9-[(1S,3R,4S)-4-(benzyloxy)-3-(benzyloxymethyl)-2-
methylenecyclopentyl]-6H-purin-6-one
|
142217-81-0 | |
| Ritonavir | ((5-Thiazolyl)methyl)-(4-nitrophenyl)carbonate(NCT) | 144163-97-3 |
|
N-[2-Isopropylthiazol-4-ylmethyl(methyl)-carbamoyl]-L-valine
(MTV-III)
|
154212-61-0 | |
|
(2S,3S,5S)-5-t-Butyloxycarbonylamino-2-amino-3-hydroxy-1,6-diphenylhexane 1/2
succinate salt (BDH succinate salt)
|
183388-64-9 | |
|
(2S,3S,5S)-5-t-Butyloxycarbonylamino-2-amino-3-hydroxy-1,6-diphenylhexane (BDH
PURE)
|
144163-85-9 | |
| Lopinavir |
N-(4-Amino-1-benzyl-3-hydroxy-5-phenyl-pentyl)-3-methyl-2-(2-oxo-tetrahydro-
pyrimidin-1-y1)-butyramide 5-oxopyrrolidine-2-carboxylic acid(THP)
|
192726-06-0 |
|
Rilpivirine
hydrochloride
|
4-[(4-Hydroxy-2-pyrimidinyl)amino]benzonitrile | 189956-45-4 |
| 4-[(4-Chloro-2-pyrimidinyl)amino]benzonitrile | 244768-32-9 | |
| (E)-3-(4-Amino-3,5-dimethylphenyl)-2-propenenitrile hydrochloride | 661489-23-2 | |
| Dolutegravir sodium |
(4R,12aS)-3,4,6,8,12,12a-Hexahydro-7-hydroxy-4-methyl-6,8-dioxo-2H-
pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid
|
1246616-73-8 |
|
(4R,12aS)-3,4,6,8,12,12a-Hexahydro-7-methoxy-4-methyl-6,8-dioxo-2H-
pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxylic acid
|
1335210-34-8 | |
|
(4R,12aS)-N-[(2,4-Difluorophenyl)methyl]-3,4,6,8,12,12a-hexahydro-7-methoxy-4-
methyl-6,8-dioxo-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide
|
1335210-35-9 | |
|
1-(2,2-Dimethoxyethyl)-5-methoxy-6-(methoxycarbonyl)-4-oxo-1,4-dihydropyridine-3-
carboxylic Acid
|
1335210-23-5 | |
| Abacavir sulfate |
N-[2-Amino-4-chloro-6-[[(1R,4S)-4-(hydroxymethyl)-2-cyclopenten-1-yl]amino]-5-
pyrimidinyl]formamide
|
171887-04-0 |
| (1S,4R)-4-(2-Amino-6-chloro-9H-purin-9-yl)-2-cyclopentene-1-methanol hydrochloride | 172015-79-1 | |
|
Oseltamivir
phosphate
|
ethyl(3R,4R,5S)-4-(tert-butylamino)-5-(diallylamino)-3-(pentan-3-yloxy)cyclohex-1-ene-
1-carboxylate hydrochloride
|
2778297-04-2 |
| ethyl(3R,4R,5S)-4-(N-(tert-butyl)acetamido)-5-(diallylamino)-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylate hydrochloride | 651324-08-2 | |
| ethyl(3R,4R,5S)-4-acetamido-5-amino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylate | 196618-13-0 | |
| Lafutidine | 2-Chloro-4-(1-piperidinylmethyl)pyridine | 146270-01-1 |
| (2-furanmethyl)thiopontoacetic acid-(4-nitrophenol)ester | 118287-86-8 | |
| Ursodeoxycholic acid | Chenodeoxycholic acid | 474-25-9 |
| Baricitinib | (4-(1-(1-ethoxyethyl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate | 1146629-76-6 |
| (4-(1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate | 1146629-77-7 | |
|
(4-(1-(3-(cyanomethyl)-1-(ethylsulfonyl)azetidin-3-yl)-1H-pyrazol-4-yl)-7H-pyrrolo[2,3-
d]pyrimidin-7-yl)methyl pivalate
|
1187595-90-9 | |
| Iguratimod | N-(4-glycyl-5-methoxy-2-phenoxyphenyl)methanesulfonamide hydrochloride | 149436-41-9 |
| N-(2-(2-methoxy-4-(methylsulfonamido)-5-phenoxyphenyl)-2-0xoethyl)formamide | 149456-98-4 | |
| N-(2-(2-hydroxy-4-(methylsulfonamido)-5-phenoxyphenyl)-2-oxoethyl)formamide | 149457-03-4 | |
| Metronidazole | 2-Methylimidazole | 693-98-1 |
| 2-Methyl-5-nitroimidazole | 88054-22-2 | |
| 2-Methyl-4,5-dinitroimidazole | 19183-16-5 | |
| Molnupiravir | 2',3'-O-(1-methylethylidene)-Uridine 4-oxime 5'-(2-methylpropanoate) | 2346620-55-9 |
| Safinamide mesylate | 4-((3-fluorobenzyl)oxy)benzaldchyde | 66742-57-2 |
| (S)-2-(4-(3-fluorobenzyl)oxy)benzyl)amino)propanamide | 133865-89-1 | |
| Baloxavir marboxil | (12aR)-7-(hexyloxy)-3,4,12,12a-tetrahydro-1H-[1,4]Oxazino[3,4-c]pyrido[2,1-f][1,2,4]triazine-6,8-dione 4-methylbenzenesulfonate | 2136287-68-6 |
|
(12aR)-12-[(S)-7,8-difluoro-6,11-dihydrodibenzo[b,e]thiazepin-11-yl]-7-(n-hexoxy)-
3,4,12,12a-tetrahydro-1H-oxazino[3,4-c]pyridinopyrimidine[2,1-f][1,2,4]triazine-6,8-
dione methanesulfonate
|
2136287-69-7 | |
|
(12aR)-12-[(11S)-7,8-difluoro-6,11-dihydrodibenzo[b,e]thiepin-11-yl]-3,4,12,12a-
tetrahydro-7-hydroxy-1H-[1,4]oxazino[3,4-cpyrido[2,1-f][1,2,4]triazine-6,8-dione
|
1985605-59-1 | |
